OrDeN

Quantum Chemical Design, Synthesis and Biological Properties of Organometallic Nucleobase Derivatives

 
Organometallic nucleobase derivatives
(OrDeNs) correspond to a new generation of conjugates in which metallocenes are linked to the basic structural elements of heredity. Due to their electrophoric and bioactive properties, OrDeNs are of use in (bio)analytical and medicinal chemistry. The preparation of OrDeNs is based on the copulation reaction between the organometallic part with a heterocyclic base, by using different linkers. The choice of fragments usually follows the target of the ever-growing diversity of structural motifs. In this project all modifications of OrDeNs structures will be directed toward derivatives with marked electrochemical and biological properties.


Equipments:


NMR spectrometer Varian INOVA 400 

IR spectrometer

Andrija cluster

Isabella cluster


Programs:

Gaussian 16

Turbomole

PcModel

Orca

Amber

 

HRZZ IP-2016-06-1137

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